Online Course on Applications of solution Nuclear Magnetic Resonance Spectroscopy in Pharmaceutical Analysis (3:0)
Objectives
The objective of the course will be to train the participants in the basic theory of NMR, the best practises in data acquisition, processing and interpretation of high-resolution solution NMR spectroscopic data of organic molecules, bioactive peptides, identification of impurities and suppression of signals from excipients. Data interpretation exercises will involve analysis of a variety of one- and two-dimensional NMR spectra. The course will also contain a module on the use of third-party software for data processing and analysis including principal component analysis and analysis of DOSY data for analysis of biomolecular aggregates.
Syllabus
Basic principles of NMR spectroscopy. NMR instrumentation. Data acquisition (one- and two-dimensional spectra, pulse calibration, shimming, spectral parameters, solvent suppression) and Diffusion Spectroscopy. Data Processing methods. Analysis of one-dimensional proton and carbon NMR spectra, two-dimensional homonuclear and heteronuclear NMR spectra. Intermolecular interactions. Introduction to software programs for data analysis and PCA analysis.
Target Group: Manufacturing / Quality Control / R & D in Pharmaceutical / Chemical industry / Agrochemical industries.
Siddhartha P Sarma
Professor
Dept. of Molecular Biophysics Unit
Indian Institute of Science
sidd@iisc.ac.in
Number of credits – 3:0
Mode of Instruction
Online Classes using Microsoft Teams Online Seats are Limited to 100
Duration
5 Months (JAN – MAY 2025)
Timings of the class
Tuesday and Thursday (8.00PM to 9.30PM )
Course Fee
₹ 15000 (Excluding 18% GST)
| Particulars | Amount (in ₹) |
| Course Fee | 15,000 |
| Application Fee | 300 |
| GST@18% | 2,754 |
| Total | 18,054 |
Who Can apply?
BSc / MSc in Chemistry / Biochemistry /
Microbiology / Biotechnology
Pre-requisites:
BSc Chemistry / Biotechnology
Reference Books
1. Basic One- and Two-Dimensional NMR Spectroscopy, 5th, Completely Revised and Updated Edition Horst Friebolin ISBN: 978-3-52782-9, December 2010, 442 pages
2. High-Resolution NMR Techniques in Organic Chemistry, 2nd Edition, Volume 2 – November 5, 2008, Author: Timothy D.W. Claridge
Language: English
Paperback ISBN: 9780080548180
Paperback ISBN: 9780080975450
Hardback ISBN: 9780080546285
eBook ISBN: 9780080915098
eBook ISBN: 9780080915036
3. 200 and More NMR experiments: A practical Course Stefan Berger, Seigmar Braun ISBN978-3-527-31067-8 834 pages